心房颤动是临床实践中常见的心律失常,其发病机理错综复杂。心肌纤维化作为房颤的主要病理基础,与房颤可互相促进,进而导致疾病的加重。基于房颤心肌纤维化的临症表现,中医可将其归于“心悸”范畴来诊治。本文从气血理论出发,结合现代药理学及临床研究,讨论气血失和与房颤心肌纤维化的相关性,探讨炙甘草汤对房颤心肌纤维化的治疗作用。研究发现,炙甘草汤诸药合用,益气养阴,补血复脉,具有保护心肌、延缓心肌重构等多重功效,能有效改善心肌纤维化状况,从而防治心房颤动。Atrial fibrillation (AF) is a common arrhythmia in clinical practice, characterized by a complex pathogenesis. Myocardial fibrosis, serving as a primary pathological substrate of AF, can mutually exacerbate AF, leading to disease progression. Based on the clinical manifestations of AF-related myocardial fibrosis, traditional Chinese medicine categorizes it under the diagnosis and treatment framework of “palpitations”. This paper, grounded in the theory of qi and blood, integrates modern pharmacology and clinical research to discuss the correlation between qi-blood disharmony and AF-related myocardial fibrosis, as well as to explore the therapeutic effects of Zhigancao Decoction on AF-related myocardial fibrosis. The study reveals that Zhigancao Decoction, through the combined actions of its constituents, tonifies qi and nourishes yin, replenishes blood, and restores the pulse. It exhibits multiple benefits including myocardial protection and delay of myocardial remodeling, thereby effectively ameliorating myocardial fibrosis and preventing AF.
