本研究旨在剖析环磷酸腺苷反应元件结合蛋白(CAMP Response Element Binding protein, CREB)相关的三种信号通路在疾病中的作用机制,以期为疾病治疗提供创新性的策略。我们采用综述的形式,通过计算机检索PubMed数据库、中国知网等权威资源,筛选并整理与CREB信号通路相关的文献资料,进行了系统的分析和探讨。在ERK/CREB信号通路的研究中,我们发现该通路对长期记忆的形成具有破坏作用以及加速抑郁症的发展。在cAMP-PKA-CREB信号通路的研究中,我们发现这一通路对乳腺癌、肺癌等多种肿瘤疾病的进展具有重要影响。同时,在CaMKII/CREB/BDNF信号通路的研究中,我们发现该通路在疼痛的维持和产生过程中起到关键作用。综上所述,我们认为CREB及其信号通路在神经系统疾病、肿瘤疾病等多种疾病中发挥着至关重要的作用。The aim of this study is to analyze the mechanism of action of three signaling pathways related to CAMP Response Element Binding protein (CREB) in diseases, with a view to providing innovative strategies for disease treatment. In the form of a review, we searched authoritative resources such as PubMed database and CNKI by computer, screened and sorted out literature related to CREB signaling pathway, and carried out a systematic analysis and discussion. In our study of the ERK/CREB signaling pathway, we found that this pathway has a destructive effect on long-term memory formation and accelerates the development of depression. In the study of cAMP-PKA-CREB signaling pathway, we found that this pathway has an important impact on the progression of breast cancer, lung cancer and other tumor diseases. At the same time, in the study of CaMKII/CREB/BDNF signaling pathway, we found that this pathway plays a key role in the maintenance and production of pain. In summary, we believe that CREB and its signaling pathway play a crucial role in a variety of diseases, such as neurological diseases and tumor diseases.
