目的探讨脉络膜血管瘤的眼底荧光血管造影(fundus flurorescence angiography,FFA)及吲哚菁绿血管造影(indocyanine green angiography,ICGA)的影像特征。方法回顾性分析9例(9只眼)脉络膜血管瘤患者的临床资料,对比分析其FFA及ICGA检查影像特征。结果FFA早期均出现形似脉络膜血管的高荧光,动静脉期荧光渗漏、逐渐增强并融合,晚期呈斑驳状强荧光。ICGA早期清晰可见不规则的脉络膜血管,中期瘤体呈强荧光,可以看出脉络膜血管瘤的边界,晚期病灶内染料排空,呈现低荧光。结论脉络膜血管瘤的FFA、ICGA图像各具特征,两者联合有助于脉络膜血管瘤的诊断。
Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine(TCM)and in chemical medicine, as well as in cosmetic ingredients, nutraceuticals and food products. Isochlorogenic acid(ICGA), which has medicinal value, has been discovered in various plants. As a widespread natural medicine, ICGA should be the subject of further research and development. However, there have been no systematic analyses of ICGA. According to our investigation, ICGA was initially isolated from green coffee extracts by Barnes et al. in 1950. To date, it has been discovered in a variety of tea, vegetables, medicinal diet and TCM materials. ICGA is used as a chemical marker for the quality control of these TCM materials. The metabolic process of ICGA has been studied in detail, conforming to be linear dynamics. Thus, the clear pharmacokinetics of ICGA offers a solid foundation for its research and development. ICGA has multiple biological and pharmacological effects, and studies have mainly focused on its antioxidant, anti-inflammatory, antimicrobial, hypoglycemic, neuroprotective, and cardiovascular protective effects, and hepatoprotective properties. The mechanisms underlying these effects are summarized in this review to provide scientific support and inspiration for the future research and development of ICGA and ICGA-rich natural products.
WANG Hao-NanSHEN ZhengLIU QingHOU Xiao-YingCAO YanLIU Da-HuiJIANG HongDU Hong-Zhi
