As a new concept having emerged in last few years,the“deep eutectic solvents”(DESs)effect integrated into the imprinting technology inevitably exposes design limitations of stimuli-responsive molecularly imprinted polymers(MIPs),as well as inadequate analysis of the adsorption performance of MIPs.Herein,a simple yet defined N-isopropylacrylamide/(3-acrylamidopropyl)trimethylammonium chloride(NIPAM/APTMAC)binary DESs system was proposed to prepare intelligent MIPs with thermo-sensitivity.Accordingly,magnetic and thermo-responsive MIPs based on functional monomers-derived DESs(TMDESs-MIPs1)were synthesized,revealing DESs effect-regulated affinity/kinetics for the enhanced adsorption capability,eco-friendly thermo-regulated elution for high release efficiency,and simple magnetic separation,along with superior selectivity to rhein(RH)and good regeneration ability.TM-DESs-MIPs1 were utilized to extract RH from Cassiae semen samples coupled with high performance liquid chromatography(HPLC),yielding satisfactory recoveries(79.47%−110.82%)and low limits of detection(LOD)(16.67μg/L).Another two kinds of MIPs adopting the thermo-responsive moiety-derived DESs effect strategy further demonstrated great applicability of such intelligent MIPs for analyses of complicated samples.
Huihuang XiongYiqun WanYong FanMengjia XuAiping YanYushan ZhangQifei JiangHao Wan
Surgical resection remains the prefer option for bladder cancer treatment.However,the effectiveness of surgery is usually limited for the high recurrence rate and poor prognosis.Consequently,intravesical chemotherapy synergize with immunotherapy in situ is an attractive way to improve therapeutic effect.Herein,a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was developed.GEM loaded PLEL hydrogel was intravesical instilled to kill tumor cells directly,then PLEL hydrogel incorporated with CpG was injected into both groins subcutaneously to promote immune responses synergize with GEM.The results demonstrated that drug loaded PLEL hydrogel had a sol-gel phase transition behavior in response to physiological temperature and presented sustained drug release,and the PLEL-assisted combination therapy could have better tumor suppression effect and stronger immunostimulating effect in vivo.Hence,this combined treatment with PLEL hydrogel system has great potential and suggests a clinically-relevant and valuable option for bladder cancer.
A complete road-soft ground model is established in this paper to study the dynamic responses caused by vehicle loads and/or daily temperature variation.A dynamic thermo-elastic model is applied to capturing the behavior of the rigid pavement,the base course,and the subgrade,while the soft ground is characterized using a dynamic thermo-poroelastic model.Solutions to the road-soft ground system are derived in the Laplace-Hankel transform domain.The time domain solutions are obtained using an integration approach.The temperature,thermal stress,pore water pressure,and displacement responses caused by the vehicle load and the daily temperature variation are presented.Results show that obvious temperature change mainly exists within 0.3 m of the road when subjected to the daily temperature variation,whereas the stress responses can still be found in deeper places because of the thermal swelling/shrinkage deformation within the upper road structures.Moreover,it is important to consider the coupling effects of the vehicle load and the daily temperature variation when calculating the dynamic responses inside the road-soft ground system.
The objective of this study is to seek solutions to reduce the impact of buildings on climate change and to promote the use of local bio-sourced or geo-sourced materials for sustainable construction. Different samples of raw earth from 3 sites were taken in the commune of Mlomp. Geotechnical tests showed that the raw earth samples from sites 2 and 3 have more clay fraction while site 1 contains more sand. The fact of integrating fibers from crushed palm leaves (Borassus aethiopum) (2%, 4% and 6%) into the 3 raw earth samples reduced the mechanical resistance to compression and traction of the 3 raw earths. The experimental results of thermal tests on samples of earth mixtures with crushed Palma leaf fibers show a decrease in thermal conductivity as well as thermal effusivity as the percentages increase (2%, 4% and 6%) of fibers in raw earth for the 3 sites. This shows that this renewable composite material can help improve the thermal insulation of building envelopes.
Mouhamadou Nabi KaneMapathe NdiayePape Moussa TouréAdama Dione
A new method for chemical pumping of gases has been developed using reactive alloys of Li with IIA metals in the liquid state. It is an answer to the need for ultra-high and extremely high vacuum without loose solid particles. Another application of this development is the production of high- and ultra-pure noble gases in a one-step process. Both of these solutions are unprecedented;they are based on a new gas/melt sorption interface that raises the overall bar of technical advances in the field to a higher level, simplifying sorption equipment and leading to cost savings.
Silicon photonics(SiPh)has emerged as the predominant platform across a wide range of integrated photonics applications,encompassing not only mainstream fields such as optical communications and microwave signal processing but also burgeoning areas such as artificial intelligence and quantum processing.A vital component in most SiPh applications is the optical phase shifter,which is essential for varying the phase of light with minimal optical loss.Historically,SiPh phase shifters have primarily utilized the thermo-optic coefficient of silicon for their operation.Thermo-optic phase shifters(TOPSs)offer significant advantages,including excellent compatibility with complementary metal-oxide-semiconductor technology and the potential for negligible optical loss,making them highly scalable.However,the inherent heating mechanism of TOPSs renders them power-hungry and slow,which is a drawback for many applications.We thoroughly examine the principal configurations and optimization strategies that have been proposed for achieving energy-efficient and fast TOPSs.Furthermore,we compare TOPSs with other electro-optic mechanisms and technologies poised to revolutionize phase shifter development on the SiPh platform.
Recently,natural draft dry cooling system with the main-auxiliary integrated air-cooled heat exchangers in the up and lower layers,has drawn attention to the electric power industry.This research firstly develops two physical models for the integrated cooling system,namely Case A and Case B.In Case A,the main air-cooled heat exchanger is arranged in the upper layer and the auxiliary air-cooled heat exchanger arranged in the lower layer,while in Case B,the two heat exchanger systems are arranged in the opposite way.And then,directing at the engineering TMCR and TRL 1 working conditions,the unit-local-overall thermo-flow characteristics of Case A and Case B are obtained and compared by numerical simulation.The findings show that,for the auxiliary air-cooled exchanger,Case A has obviously higher cooling performances than Case B,with the difference varying from 5.46%to 7.55%.Whereas,for the main air-cooled exchanger,Case B shows the recovered cooling performances,with the difference changing from 1.15%to 2.99%.Case A is preferably recommended to the engineering application in consideration of more strict cooling demand of the auxiliary cooling system.Conclusively,this research will provide some theoretical guidelines for the design and construction of the main-auxiliary integrated natural draft dry cooling system.
