＜正＞A series of 5-N-methylated quindoline derivatives were designed and synthesized to develop potent telomeras...
Yu-Jing Lu Tian-Miao Ou Ning Sun Jia-Heng Tan Zhi-Shu Huang~* Lian-Quan Gu~* School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510275,China
1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one (1a) took place a cycli- zation, debenzylation and oxidation to form 9-substitued benzo[de]chromene-7,8-dione (2a) and 5-benzyl-9-substitued benzo[de]chromene-7,8-dione (3a). The mechanisms for these reactions were discussed.
Shi Liang HUANGYi LUOZhi Shu HUANGXian Zhang BUPei Qing LIULin MAYue Ming LIAlbert S. C. CHANLian Quan GU
A new bisbenzofuran analogue VII was achieved unexpectedly in one step procedure from 1-(4-methoxyphenoxy)acetone I by using Amberlyst 15 resin as catalyst in excellent yield. The structure was elucidated by spectroscopy analysis including 1H-NMR, 13C-NMR, DEPT, ESI-MS, element analysis.
Yu Dong SHENHai Qiang WULin Kun ANZhi Shu HUANGXian Zhang BULian Quan GU
A series of novel phenoxazinone derivatives (1-6) were designed and synthesized for evaluating their antitumor activities. The antiproliferative activities of the prepared compounds against representative human neoplastic cell lines were evaluated by MTT assay. The results showed that most of them inhibited cell proliferation in a submicromolar to micromolar range. These compounds were also evaluated against KBv200 and MCF-7/Adr cell lines, which overexpress the MDR/P-glycoprotein drug efflux pump responsible for drug resistance, and had a more potential for resisting MDR than their lead compound APO.
Ji Wu RUANZhi Shu HUANGJin Feng HUANGCui Juan DUShi Liang HUANGZhi SHILi Wu FULian Quan GU
