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国家自然科学基金(11374297): 作品数：4 被引量：11H指数：2; 相关作者：孔祥贵张友林李晓坤赵慧颖夏安东更多>>; 相关机构：中国科学院长春光学精密机械与物理研究所中国科学院大学中国科学院更多>>; 发文基金：国家自然科学基金国家重点实验室开放基金更多>>; 相关领域：理学更多>>

In vivo 808nm Image-Guided Photodynamic Therapy based on Upconversion Theranostic Nanoplatform: ＜正＞A new strategy for efficient in vivo image-guided photodynamic therapy（PDT） has been demonstrated utilizing...; Xiaomin LiuXiaodan LiXianggui KongYajuan SunHong ZhangYoulin ZhangLangping TuYulei ChangHuiying Zhao; 文献传递

Novel Upconversion Photosensitizer Excied by Light of 980nm for Simultaneous Luminescence Imaging and Photodynamic Therapy of Cancer: ＜正＞Photodynamic therapy（PDT） is defined as the site-directed generation of cytotoxic effects upon targeted lig...; Lu XiaXianggui KongXiaodan LiYoulin ZhangLangping TuYulei ChangHuiying Zhao; 文献传递

Trimetallic Au@PdPt core-shell nanoparticles with ultrathin PdPt skin as highly stable electrocatalysts for the oxygen reduction reaction in acid solution被引量：2: 2019年; To design efficient and low-cost core-shell electrocatalysts with an ultrathin platinum shell, the balance between platinum dosage and durability in acid solution is of great importance. In the present work, trimetallic Au@PdPt core-shell nanoparticles(NPs)with Pd/Pt molar ratios ranging from 0.31:1 to 4.20:1 were synthesized based on the Au catalytic reduction strategy and the subsequent metallic replacement reaction. When the Pd/Pt molar ratio is 1.19:1(designated as Au@Pd_(1.19) Pt_1 NPs), the superior electrochemical activity and stability were achieved for oxygen reduction reaction(ORR) in acid solution. Especially, the specific and mass activities of Au@Pd_(1.19) Pt_1 NPs are 1.31 and 6.09 times higher than those of commercial Pt/C catalyst. In addition, the Au@Pd_(1.19) Pt_1 NPs presented a good durability in acid solution. After 3000 potential cycles between 0.1 and 0.7 V(vs. Ag/AgCl), the oxygen reduction activity is almost unchanged. This study provides a simple strategy to synthesize highperformance trimetallic ORR electrocatalyst for fuel cells.; Xiaokun LiChunmei ZhangCheng DuZhihua ZhuangFuqin ZhengPing LiZiwei ZhangWei Chen; 关键词：ELECTROCATALYST CORE-SHELL PLATINUM NANOPARTICLE

Drug Nanocarrier properties of Luminescence Upconversion Nanostructure with Monodisperse NaYF4:Yb3+,Er3+ Core/Mesoporous Silica Shell: ＜正＞In recent years,mesoporous silica has been extensively studied with regard to its potential application in ...; Fei WuXianggui KongXiaodan LiBin XueYoulin ZhangLangping TuYulei ChangHuiying Zhao; 文献传递

A Novel Design of Optical Switch Based on Up-and Down-conversion Luminescence nanocrystal used in BSA Detection: ＜正＞A novel prototype design of optical switch based on FRET between up-and Down-conversion luminescence nanocr...; Li PangXiaodan LiLi ZhangXiaomin LinYajuan SunYi YuHuiying Zhao; 文献传递

量子点尺寸对量子点和金纳米粒子之间的荧光共振能量转移的影响被引量：1: 2014年; 量子点(QDs)所具有的一元激发多元发射的特点预示着QDs在高通量的多元量化生物信息处理领域具有应用前景。采用柠檬酸钠直接还原法制备了粒径为15 nm的Au纳米粒子,利用静电自组装的方法构建了Au与QDs的荧光共振能量转移(FRET)系统。采用该系统研究了QDs的尺寸变化对FRET效率的影响,获得了FRET效率和给体与受体之间交叠积分的关系。结果证明,QDs是构建多元均相免疫检测技术的一个有效给体。; 李晓坤张友林孔祥贵; 关键词：量子点金纳米粒子荧光共振能量转移

Optical fiber biosensor based on nano-photonics for immunoassay of in vivo in situ biomolecules: ＜正＞The fluorescence immunoassay based serum separation has been generally used in present medical clinic diagn...; Xianggui KongXiaodan LiBin XueYoulin ZhangLangping TuYulei ChangHuiying Zhao; 文献传递

Studies on Mechanism of Nanocytotoxicity and Subcellular Dynamics of Upconversion Nanoparticles with Different Surface Charges: ＜正＞Intensive investigations have been devoted to lanthanide-doped upconversion nanoparticles（UCNPs）,which have...; Xianggui KongXiaodan LiXiaomin LiuHuiying Zhao; 文献传递

K离子掺杂增强NaErF4体系上转换发光: 2018年; 制备了一系列Na_(1-x)K_xErF_4@NaLuF_4的核壳纳米结构,核中K^+掺杂摩尔分数变化范围为0%~8%。XRD分析结果揭示这些具有不同K掺杂浓度的纳米粒子均为!-相纳米结构。研究结果表明:随着K^+浓度的增加,纳米结构中Er^(3+)~650 nm处的红带发光强度呈现先增强后减弱的规律,当K^+摩尔分数为4%时,Na_(0.96)K_(0.04)ErF_4@NaLuF_4纳米晶的发光强度达到最大,为未掺杂K^+的NaErF_4@NaLuF_4纳米晶发光强度的3.7倍。其发光增强的原因在于K^+的掺杂降低了Er^(3+)微环境晶场宇称对称性,提高了Er^(3+)离子~4F_(9/2)→~4I_(5/2)能级辐射跃迁几率,进而增强了Er^(3+)的650 nm红带的上转换发光强度。; 张美玲周进张俐李齐清涂浪平薛彬赵慧颖施展夏安东孔祥贵; 关键词：稀土离子上转换发光发光效率

Ag纳米粒子聚集体的SiO_2包覆及其SERS效应被引量：8: 2014年; 为实现表面增强拉曼散射(SERS)信号的快速检测分析,报道了一种简单的利用SiO2包覆对巯基苯甲酸(4MBA)修饰的Ag纳米粒子形成核壳结构纳米颗粒SERS标记物的方法。通过调控溶液中硝酸钠的浓度来控制4MBA-Ag的聚集程度,获得不同的"热点"效应,然后利用SiO2包覆实现对聚集体的固定。扫描电镜结果证实此种方法非常有效。该体系中SERS的信号强度依赖于4MBA-Ag的聚集程度。该研究结果有助于实现聚集体SERS标记物在生物成像、检测和传感等方面的应用。; 李晓坤张友林孔祥贵; 关键词：表面增强拉曼散射银纳米粒子

国家自然科学基金(11374297)