Nonequilibrium molecular dynamics (MD) method was used to study the dielectrophoresis (DEP) motion of nanocolloids in non-uniform electric field. By changing the electric field strength and system temperature, aggregation phenomena of nanocolloids was analyzed. Simulation results showed that at normal temperature, though the Brownian force can affect the motion of colloids, the attractive force will increase quickly with the distance between colloids down to 12σ , which makes colloids aggregate. When the Brownian force is weak to colloid's motion, for the enhancement of electric field strength, the DEP force of colloid will increase and so did the attractive force, which finally quickens the aggregate speed. Simulation results also showed that the temperature' enhancement will increase the Brownian force of colloids, hence disturbing the colloids aggregation. Moreover, the DLVO theory was used to study the motion of a pair of interactional colloids, both the potential energy and the attractive force versus distance of colloids were presented, then the latter graph was used to compare with another graph elicited by MD method. Results showed that the two graphs were nearly the same, indicating the MD model accorded with the theory.
On the basis of the research on the status and problems of micro/nano bio-particles manipulation using dielectrophoresis, the theoretical basis and the model simulation of micro/nano bio-particles manipu-lation using light-induced dielectrophoresis were discussed. The space distribution of electric field and dielectrophoresis forces in different heights were also obtained. On this basis, the core component of the micro manipulation system, that is, photoconductive layer of the chip, was completed in the mate-rial selection, fabricating process and performance analysis testing. Then the voltage drop of the sus-pension and the effective voltage frequency spectrum were obtained. Finally, by combining the machine vision detection with real-time tracking system, the micro/nano bio-particles manipulation platform based on the light-induced dielectrophoreisis was established, and then the manipulations for micro/nano bio-particles, such as quick collection, transport, separation, were implemented. This provided a basis for rapid, accurate, and low-cost detection of serious diseases based on the micro-fluidic biochip and early diagnosis.
The nonequilibrium molecular dynamics (MD) method was used to model the nanocolloids and the solvent particles. By introducing a non-uniform electric field, colloids were polarized to have opposite polarities. Separation of colloids driven by dielectrophoresis (DEP) could be seen clearly under a strong electric field at low temperatures. Analyzing the ratio of DEP velocities of colloids to thermal velocities of neutral solvent particles showed that when the ratio was correspondingly big, collision between colloids and solvent particles would be intense, making the DEP velocity of colloids fluctuate frequently. By changing the electric field strength, it was found that the enhancement of electric field strength would quicken the separation of colloids. But when the electric field strength increased to a certain degree, the separation motion would be slow because of the strong friction resistance of the solvent particles to the colloids. Moreover, studying the separation reason of colloids based on the potential energy showed that after colloids were polarized, the attractive potential energy among the colloids would be weaker than before, while the increase of temperature would reduce the attractive potential energy and increase the repulsive potential energy, which accorded with the DLVO theory.
