In order to study the correlation between the neuroendocrine and immune systems, we observed the distribution and expression of interferon γ(IFN-γ) in cells of SD rat pancreas islets using the streptavidin-perosidase immunohistochemical method. A number of IFN-γ-like positive substances were found in the in the cytoplasm of pancreas islet A cells, but the nucleus could not be stained. Most of the IFN-γ-like positive cells were distributed around the periphery of the pancreas islet, the cells were round or oval in shape and the cell body was relatively large. Results suggest IFN-γ may play a role in the regulation of the function of pancreas islet cells and act as a neuro-immune medium .
