We report an effcient kinetic resolution of racemic 2-(4-chlorophenyl)-4-hydroxytetrahydro-pyran(CLP-4-HTHP)via Pseudomonas cepacia lipase(PSL)-catalyzed transesterifcation,where PSL is immobilized on a core–shell MnFe2O4@SiO2-(CH2)3-NH2carrier and used as a magnetically separable catalyst.The as-synthesized PSL/MnFe2O4@SiO2-(CH2)3-NH2catalyst exhibits enhanced catalytic activity for resolving racemic CLP-4-HTHP to the corresponding optically pure(2R,4S)-CLP-4-HTHP compared to the free PSL.The ees for the former is 2.3 times larger than that for the latter under optimized conditions(99.4%and 44.1%,respectively),although the eep for them are same(99.2%).Meanwhile,the PSL/MnFe2O4@SiO2-(CH2)3-NH2catalyst possesses a high saturate magnetization of59.7 emu/g and could be easily recovered by magnetic separation and reused.The catalytic activity in six recycling tests did not signifcantly decrease,suggesting its great potential for industrial applications.
Ping XueZhen-Zhen KangXiao-Yong LaiGuan-Qun QuYuan-Yuan Li
