A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substituted atyl chlorides could efficiently react with heterocycles, providing variety of N-arylated products in good to excellent yields. The ligand-free catalyst system was stable in air and could be readily reused.
A sequential one-pot synthesis of N-sulfonylcyclothioureas from N-monosulfonyl diamines, CS2 and chloroace- tic acid at room temperature in water is described. In the absence of highly toxic thiophosgene and organic solvents, this method is environmentally benign. Simple reaction conditions, easy purification of the products, good yields and thioglycolic acid as the useful byproduct are also important attributes of this methodology. The plausible mechanism including tandem reactions is proposed.
Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cyclization of intramolecule at room temperature in aqueous solution. The advantages of the novel protocol are the mild reaction condition, free organic solvent, simple final treatment, easy isolation of products and excellent yields.
Graphite oxide （GO） has attracted much attention of material and catalysis chemists recently. Here we describe a combination of GO and molecular sieves for the dehydrogenative aromatization. GO prepared through improved Hummers method showed high oxidative activity in this reaction. Partially or fully saturated aromatic compounds were converted to their corresponding dehydrogenated aromatic products with fair to excellent conversions and selectivities. As both GO and molecular sieves are easily available, cheap, lowly toxic and have good tolerance to various functional groups, this reaction provides a facile approach toward aromatic compounds from their saturated precursors
