背景：MRI在膝关节色素沉着绒毛结节性滑膜炎中具有特异性影像征象，并具有极高的临床价值。目的：分析膝关节色素沉着绒毛结节性滑膜炎的MRI影像学特征及诊断价值。设计、时间及地点：单一样本观察，于2007—02／2009-03在汕头大学医学院第一附属医院完成。对象：选择汕头大学医学院第一附属医院骨外科手术病理证实的色素沉着绒毛结节滑膜炎患者15例，男9例，女6例，年龄18-67岁，病程3个月～7年。7例行关节镜下滑膜切除，8例行开放性滑膜切除。方法：采用Philips 1．5T Power 6000MR超导型MRI扫描仪对患者膝关节表面矢状位、冠状位扫描。主要观察指标：色素沉着绒毛结节性滑膜炎患者MRI征象及病理所见。结果：局限型2例，弥漫型13例。色素沉着绒毛结节性滑膜炎主要表现为滑膜不规则结节状增生或弥漫性增生，增生的滑膜内含铁血黄素沉着（T2WI低信号）、邻近半月板和（或）骨侵蚀、关节腔积液等。结论：MRI能为早期诊断膝关节色素沉着绒毛结节性滑膜炎提供依据。
OBJECTIVE To investigate cyclin D1 expression in peripheral lung cancers and its relationship with CT signs and prognosis. METHODS Cyclin D1 expression in peripheral lung cancers and its relationship with the CT imaging and prognosis were analyzed retrospectively by means of SP immunohistochemistry and spiral CT scanning in 92 patients with peripheral lung cancer verified by pathology. RESULTS Cyclin D1 expression was related to deep lobulation,spiculate protuberance,short thin spinules sign and mediastina lymph node metastasis.Cyclin D1 expression was not related to tumor size,cavity,pleural indentation,histological type,differentiation,tumor TNM stage,age or sex.Cyclin D1 was a negative prognostic factor whose over-expression indicated a poor prognosis. CONCLUSION Cyclin D1 expression may play an important role in the occurrence,progress and CT scan results of lung cancers.Cyclin D1 was a negative factor whose over-expression implied a poor prognosis.Detection of the cyclin D1 and observation of the CT scan can be considered as indexes of clinical diagnosis and prognostic evaluation.
