＜正＞Molecular recognition of ATP by proteins,a subject of great importance for understanding enzymatic mechanis...
Jihong Liu~(a,b),Shuxia Cao~(a,*),Daxiong Hanc,Zhiping Zeng~c,Jiansha Lu~a,Xincheng Liao~a,Yufen Zhaoa,~(c,d*) a Key Laboratory of Chemical Biology and Organic Chemistry,Department of Chemistry,Zhengzhou University,Zhengzhou,450052,P R.China b Research Center of Agricultural Quality Standards and Testing Techniques,Henan Academy for Agricultural Sciences,Zhengzhou,450002,P R.China c The Key Laboratory for Chemical Biology of Fujian Province,Department of Chemistry and College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,P R China d The Key Laboratory of Bioorganic Phosphorus Chemisty & Chemical Biology,Ministry of Education, Department of chemistry,Tsinghua University,Beijing,100084,P R.China
五多原子的 cyclotriphosphazene ligands 为他们的劈开活动被综合并且测试到原生质标志 DNA。所有被 MS 这些新混合物证实， 1 H NMR， 31 P NMR， 13 C NMR 和红外。pUC19 DNA 的劈开上的初步的研究面对金属建筑群被执行。结果表明这些建筑群能在生理的条件下面充当强大的催化剂。建筑群 3b + Cu 能有效地劈开 DNA 到 nicked 形式，给水解作用在生理的条件下面的 0.08/h 的率常数。acid–；基础催化 DNA phosphate-diester 水解作用机制也被建议。
The DNA binding and cleavage activity of a synthetic polyamide containing dipeptide Ser-His has been investigated by spectroscopic techniques, such as electronic absorbance and circular dichroism (CD) spectropolarimetry, as well as gel electrophoresis. The results show that the molecule has a strong interaction with DNA and can improve DNA-cleavage ability about 100 fold as compared with single dipeptide Ser-His.
