Curcumin(N1),demethoxycurcumin(N2) and bisdemethoxycurcumin(N3) were isolated from the extract of Curcuma longa(turmeric),and curcumin derivatives(N11～N14) were synthesized.Curcuminoids and curcumin derivatives were evaluated in vitro for the aldose reductase inhibitory activity.The results showed that curcuminoids and curcumin derivatives with hydroxyl or carboxyl acid groups exerted inhibitory activities on aldose reductase,and curcuminoid(N1) and curcumin derivative compound(N13) exhibited potential inhibitory activities.
A Brφnstd acidic ionic liquid HSO4 was used as catalyst in the esterification of acrylic acid and diethylene glycol.The influencing factors were studied.Under the optimized condition:n(diethylene glycol)∶n(acrylic acid)was 1.0∶2.4(0.1mol diethylene glycol,0.24mol acrylic acid),reaction time was 60 min,temperature was 115～120℃,the dosage of catalyst was 2.5% of the total reactants(mol),water-carrying agent was 30mL of toluene,the yield of the diethylene glycol diacrylate was 98.0% in the esterification of acrylic acid and diethyleneglycol glycol.
