A mangrove endophytic fungus(No.1947)was isolated from the leaves of Kandelia candel from all estuarine mangrove from the South China Sea.The secondary metabolites of this strain were studied firstly in this paper and five compounds were isolated from the fermentation liquid.Their structures were elucidated by spectroscopy methods as three cyclodipeptides,cyclo-(Tyr-Tyr),cyclo-(Leu-Leu)and cyclo-(AIa-Leu),and Uracil and 5-isobutyl-2,4-imidazolidinedione.The results show that this fungal strain can produce abundant azacyclic compounds.
Eight 1,2-disubstituted cyclododecenes were synthesized from -alkoxycarbonyl-cyclododecanone and alkyl chloroformate. Their configuration and conformation determined by IR, NMR spectroscopy and X-ray diffraction analysis showed that the carbon-carbon double bond of all of the synthesized compounds has cis-configuration, and the ring skeleton of their preferred conformation is [1ene2333] in solid, and they may adopt two different [1ene2333] conformations,which exist in a dynamic equilibrium in solution.
