6-(Bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol(compound 9) was synthe sized from 6-methylpyrimidine-2,4-diol(compound 1) through the crucial steps of 6-methyl alkylating and intramo lecular cyclization. The assignment of the structure of compound 9 was performed by its spectral data, 1H NMR, 13C NMR, HMBC, and HRMS spectra.
LIU Wei-dong2, DENG Xi-ling2, ZHANG Zhi-li2, WANG Xiao-wei2 and LIU Jun-yi1,2 1. State Key Laboratory of Natural and Biomimetic Drug, 2. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China
