The microscopic optical potential of nucleus-nucleus interaction is presented via a folding method with the isospin dependent complex nucleon-nuclear potential,which is first calculated in the framework of the Dirac-Bruecker-Hartree-Fock approach. The elastic scattering data of 6He at 229.8 MeV on 12C target are analyzed within the standard optical model. To take account of the breakup effect of 6He in the reaction an enhancing factor 3 on the imaginary potential is introduced. The calculated 6He+12C elastic scattering differential cross section is in good agreement with the experimental data. Comparisons with results in the double-folded model based on the M3Y nucleon-nucleon effective interaction and the few the body Glaubermodel calculations are discussed. Our parameter free model should be of value in the description of nucleusnucleus scattering,especially unstable nucleus-nucleus systems.