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Iron regulatory proteins were involved in the 6-hydroxydopamine induced ferroportin1 and hephaestin down-regulation in MES23.5 cells: ＜正＞Our previous study demonstrated that ferroportinl（FP1）and hephaestin（HP）may account for the nigral iron acc...; SONG Ning; 关键词：HEPHAESTIN 6-HYDROXYDOPAMINE IRON; 文献传递

Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats: The effects of myricetin on 6-hydroxydopamine induced neurodegeneration in the substantia nigra-striatum syste...; Ze-Gang MA,Jun-Xia XIE Department of Physiology,Faculty of Medicine,Qingdao University,Qingdaog 266071,China; 关键词：MYRICETIN 6-HYDROXYDOPAMINE IRON ANTIOXIDANT; 文献传递

Ceruloplasmin is involved in the nigral iron accumulation of 6-OHDA lesioned rats: ＜正＞Elevated iron levels in the substantia nigra participate in neuronal death in Parkinson’s disease（PD）.While...; Jun WANG,Hong JIANG,Jun-Xia XIE Department of Physiology,Medical College,Qingdao University,Qingdao 266021; 关键词：6-OHDA CERULOPLASMIN IRON; 文献传递

Ghrelin protects dopaminergic neurons in the substantia nigra from MPTP- induced neurodegeneration in vivo: The aim of the study was to investigate the anti-apoptotic effect of an endogenous neuropeptide,ghrelin on the...; Lin-Jing LI,Hong JIANG,Jun WANG,Jun-Xia XIE~* Medical college of Qingdao university,Qingdao 266071,China; 关键词：GHRELIN; 文献传递

Copper(Cu2+)-induced damages of dopaminergic neurons in the nigrostriatal system of rats: Clinical studies have demonstrated an excess of copper in the substantia nigra(SN) of patients with Parkinson'...; Wenran YU,Hong JIANG,Jun-Xia XIE~* Department of Physiology,Qingdao University Medical College,Qingdao 266071; 关键词：COPPER STRIATUM NEURODEGENERATION; 文献传递

Recent progress in neurodegenerative disorder research in China被引量：34: 2010年; Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging populations.In the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by Chinese neuroscientists.Their findings include the description of Chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.; ZHOU JiaWei Institute of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,200031; 关键词：NEURODEGENERATIVE DISORDERS NEUROPROTECTION DISEASE DISEASE

DMT1第四功能区腺病毒表达载体的构建及其功能的初步研究: 2007年; 目的:构建携带DMT1第四功能区基因的重组腺病毒表达载体,并对其功能进行初步探讨。方法:采用AdEasy系统构建携带DMT1第四功能区基因的重组腺病毒载体pAd-DMT1-4,脂质体法转染人胚肾293细胞,包装产生重组腺病毒vAd-DMT1-4。vAd-DMT1-4感染C6胶质瘤细胞后,采用RT-PCR检测目的基因表达,用铁孵育感染重组腺病毒的靶细胞后,测定C6胶质瘤细胞内OH.和MDA含量。结果:PCR、序列测定以及限制性酶切证实vAd-DMT1-4基因正确插入穿梭质粒,并与病毒骨架质粒pAdEasy-1重组,重组腺病毒表达载体构建成功。经293细胞包装获得具有稳定感染性的重组腺病毒vAd-DMT1-4,感染重组腺病毒的C6胶质瘤细胞DMT1-4表达增加。用铁孵育感染重组腺病毒的靶细胞后,C6胶质瘤细胞内OH.和MDA含量有增高的趋势。结论:重组腺病毒vAd-DMT1-4可有效感染C6胶质瘤细胞。; 王蕾姜宏徐华敏罗兵谢俊霞; 关键词：DMT1 腺病毒载体

Up-regulated divalent metal transporter 1 by 1-MethyI-4-phenyI- pyridinium iodide(MPP+) enhances iron induced cell apoptosis in MES23.5 cells: Based on the previous study,we assume that newly discovered iron transporter,divalent metal transporter 1 (DMT...; Shuzhen ZHANG,Jun WANG,Ning SONG,Hong JIANG~*,Jun-Xia XIE~* Department of Physiology,Medical College of Qingdao University,Qingdao,266071; 关键词：MPP+; 文献传递

Neurotoxic effect of zinc on MES23.5 dopaminergic cells: Evidence demonstrated that the Zn level in the substantia nigra（SN） of patients with Parkinson's disease（PD） i...; Limin SHI,Jun WANG,Hong JIANG,Jun-Xia XIE~* Department of physiology,Medical college of Qingdao University,Qingdao,266071; 关键词：APOPTOSIS; 文献传递

RNA interference for inhibition of DMT1 expression: Objective DMT1-Divalent Metal(Ion) Transporter 1 or SLC11 A2/DCT1/Nramp2 - transports Fe2+ into the duodenum a...; Bing LUO,Hong JIANG,Jun-Xia XIE Department of Physiology,Medical College of Qingdao University,Qingdao 266071,China; 关键词：SHRNA DMT1; 文献传递

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国家重点基础研究发展计划(2006CB500704)