[ Objective] The aim of this study is to construct the model for simple obesity induced by high-fat diet, which is closest to human obesity, laying a foundation for the studies of obesity related theories. [Method[ ICR and KM mice, half male and half female, were randomly divided into the high-fat diet experimental group and the normal diet control group based on body weights, and certain days later, body weight, Lee＇ s index, wet weight of adipose tissue, quantity of adipose cell in the same visual field and blood indices were measured. [Result]All indices mentioned a- bove of the female I CR mouse had significant statistical differences with those of the control group （P 〈 0.01 or P 〈 0.05）. [ Conclusion] To con- struct mouse nutritional obesity model successfully, different high-fat diets are required by different lines as well as different sexes in the same line.
