Background：Hepcidin,as a regulator of body iron stores,has been recently discovered to play a critical role in the pathogenesis of anemia of chronic disease.Atherosclerotic cardiovascular disease is the most common complication and the leading cause of death in chronic hemodialysis （CHD） patients.In the current study,we aimed to explore the relationship between serum hepcidin and uremic accelerated atherosclerosis （UAAS） in CHD patients with diabetic nephropathy （CHD/DN）.Methods：A total of 78 CHD/DN and 86 chronic hemodialyzed nondiabetic patients with chronic glomerulonephritis （CHD/non-DN） were recruited in this study.The level of serum hepcidin-25 was specifically measured by liquid chromatography-tandem mass spectrometry.Serum levels of interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured by enzyme-linked immunosorbent assay.Results：High serum level ofhepcidin-25 was seen in CHD patients.Serum hepcidin-25 in CHD/DN was significantly higher than that in CHD/non-DN patients.Serum hepcidin-25 was positively correlated with ferritin,high-sensitivity C-reactive protein （hs-CRP）,TNF-α,and IL-6 in CHD/DN patients.CHD/DN patients exhibited higher common carotid artery intima media thickness （CCA-IMT）,hs-CRP,and hepcidin-25 levels than that in CHD/non-DN patients.Moreover,in CHD/DN patients,CCA-IMT was positively correlated with serum hepcidin,hs-CRP,and low-density lipoprotein-cholesterol.On multiple regression analysis,serum hepcidin and hs-CRP level exhibited independent association with IMT in CHD/DN patients.Conclusions：These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.
Han LiSu-Juan FengLu-Lu SuWei WangXiao-Dong ZhangShi-Xiang Wang
Background： Hydrogen sulfide （H,S） plays a protective role in chronic hemodialysis （CHD） patients. In this study, we further investigate the relationship between H,S and conventional protein kinase CβII （cPKCβII） in CHD patients with uremic accelerated atherosclerosis （UAAS）. Methods： A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS （CHD ＋ AS） were studied. Plasma H,S was measured with a sulfide sensitive electrode, and cPKCβ11 membrane translocation was detected by Western blotting. Results： Plasma H2S in CHD ＋ AS group was significantly lower than that in CHD patients, cPKCβII membrane translocation in CHD ＋AS group increased significantly compared with CHD group. Plasma H,S concentration was negatively correlated with cPKCβ11 membrane translocation in CHD ＋ AS patients. Conclusions： These findings suggest a possible linkage between H,S metabolism and cPKCβ11 activation, which may contribute to the development of UAAS in CHD patients.
Wei WangSu-Juan FengHan LiXiao-Dong ZhangShi-Xiang Wang
Background The prevalence of sleep disorders has been shown to be high in patients with chronic dialysis patients and may contribute to impaired quality of life and higher mortality in this population.However,there are few data on the relationship of sleep disorders and their risk factors in chronic dialysis patients.The aim of this study was to evaluate the relationship of sleep disorders and their risk factors in chronic dialysis patients.Methods A total of 42 continuous ambulatory peritoneal dialysis （CAPD） patients were involved in this cross-sectional study.Sleep quality was assessed by the Pittsburgh Sleep Quality Index （PSQI）.Restless legs syndrome （RLS） was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group.And depression was assessed by Hamilton depression scale.General information and laboratory data were collected.Results The prevalence of sleep disorders was 47.6％ in the CAPD patients.According to the PSQI,the 42 CAPD patients were divided into sleep disturbance group and non-sleep disorders group.There were no significant differences in age,gender,dialysis duration,hemoglobin,serum creatinine,urea nitrogen,β2-microglobulin,parathyroid hormone,calcium,and phosphorus between CAPD patients with sleep disorders and those without sleep disorders.But the level of serum albumin （AIb） in CAPD patients with sleep disorders was significantly lower than that in CAPD patients without sleep disorders （31.3±1.4 vs.34.3±3.7,t=3.603,P=0.001）.And the prevalence of RLS and depression was significantly higher than that in CAPD patients without sleep disorders （RLS：11/22 vs.1/20,x2=10.395,P=0.001; depression：7/22 vs.1/20,x2=4.886,P=0.027）.In CAPD patients with RLS,the prevalence of sleep disorders was significantly higher than that in CAPD patients without RLS （11/22 vs.11/30,x2=10.395,P=0.001）.And in CAPD patients with depression,the prevalence of sleep disorders was significantly higher than that in CAPD patients without depression （7/8 vs
Li HanLi XiaobeiFeng SujuanZhang GuizhiWang WeiWang Shixiang
