Background Ciliary body tumors are usually difficult to diagnose and treat in early stages. However, treatment of such tumors has trended toward ocular conservation instead of enucleation. Local excision of ciliary body tumors has become effective with the development of the modern vitrectomy, but long-term outcomes are still not clear. Therefore, we reported the outcome of locally excised ciliary body tumors after long-term follow-up. Methods Twenty-two patients （22 eyes）, who had been diagnosed with ciliary body tumors in Beijing Tongren Hospital from January 1996 to June 2001, were enrolled in this prospective cohort study. Localized lamellar sclera-ciliary excisions were performed. In some cases, vitrectomies, scleral graft transplantations, and further excisions of the anterior choroid were performed. Diagnoses were confirmed by histopathologic examination. Patients were followed from five to eleven years after surgery. Their visual acuity, intraocular pressure and local recurrence were recorded with descriptive percentages. Results After surgery, all patients maintained normal eyeball appearances. Six patients maintained circular pupils. The final best corrected visual acuities （BCVA） varied from 0.02-1.00, including 18 patients （81.82%） who had BCVA equal to or better than that before surgery. Fifteen patients （68.18%） had BCVA better than 0.3. Only two patients had intraocular pressure （lOP） of less than 10 mmHg and the other patients maintained normal lOP. Nine cases （40.91%） were given confirmed diagnosis of malignant melanoma, four （18.18%） of melanocytoma, six （27.27%） of nonpigmented ciliary epithelial adenoma, two （9.09%） of neurofibroma, and one （4.55%） of neurinoma. Twenty patients （90.91%） had no recurrence during the follow-up period. In one case melanocytoma recurred seven years after surgery and enucleation was performed. One patient, whose operation removed a malignant melanoma with a diameter of 16 mm, died of hepatic metastasis five years after th
Oculodermal melanocytosis （ODM） is a congenital melanocytic pigmentary disorder involving eyetissue. It is a congenital ocular pigmentation with associated melanocytic deposition in the surrounding dermis. In 1939, Ota and Taninol first gave a definitive description of cutaneous hyperpigmentation along the trigeminal nerve distribution in addition to bulbar involvement, called oculodermal melanocytosis （nevus of Ota）. Oculodermal melanocytosis is a well-recognized risk factor for the development of choroidal malignant melanoma, especially in white patients. Gonder et al2,3 reported ODM is about 35 times more common in the uveal melanoma population. We report three cases of choroidal malignant melanoma in oculodermal melanocytosis patients.
YANG Qiong WEI Wen-bin YANG Wen-li LI Bin WANG Guang-lu
The miRNA expression profile was initially established to investigate its corresponding function in human uveal melanoma. The miRNA expression profile in human uveal melanoma was analyzed by a micro chip technique.The hsa-miRNA expression between four uveal melanomas and four normal uveal tissues was compared.Based on the bioinformatic approach,chip data was analyzed to select out differentially expressed candidate hsa-miRNAs.Real-time quantitative PCR(RT-PCR) was used to confirm the candidate hsa-miRNAs expression in all samples.The results of miRNA microarray chips that matched with RT-PCR were considered as the miRNA expression which was significantly different between normal tissue and uveal melanomas.In four uveal melanomas,expressions of miRNA-20a,miRNA-106a,miRNA-17,miRNA-21,and miRNA-34a were significantly up-regulated,while miRNA-145 and miRNA-204 expression were significantly down-regulated.We used miRNA microarray analysis as a fast,efficient technology to study biological information.The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis,and may help promote the diagnosis and treatment for uveal melanoma.
