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作品数:10 被引量:57H指数:4
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International non-governmental organizations’provision of communitybased tuberculosis care for hard-to-reach populations in Myanmar,2013-2014
2017年
Background:National tuberculosis(TB)programs increasingly engage with international non-governmental organizations(INGOs),especially to provide TB care in complex settings where community involvement might be required.In Myanmar,however,there is limited data on how such INGO community-based programs are organized and how effective they are.In this study,we describe four INGO strategies for providing community-based TB care to hard-to-reach populations in Myanmar,and assess their contribution to TB case detection.Methods:We conducted a descriptive study using program data from four INGOs and the National TB Program(NTP)in 2013-2014.For each INGO,we extracted information on its approach and key activities,the number of presumptive TB cases referred and undergoing TB testing,and the number of patients diagnosed with TB and their treatment outcomes.The contribution of INGOs to TB diagnosis in their selected townships was calculated as the proportion of INGO-diagnosed new TB cases out of the total NTP-diagnosed new TB cases in the same townships.Results:All four INGOs implemented community-based TB care in challenging contexts,targeting migrants,post-conflict areas,the urban poor,and other vulnerable populations.Two recruited community volunteers via existing community health volunteers or health structures,one via existing community leaderships,and one directly involved TB infected/affected individuals.Two INGOs compensated volunteers via performance-based financing,and two provided financial and in-kind initiatives.All relied on NTP laboratories for diagnosis and TB drugs,but provided direct observation treatment support and treatment follow-up.A total of 21995 presumptive TB cases were referred for TB diagnosis,with 7383(34%)new TB cases diagnosed and almost all(98%)successfully treated.The four INGOs contributed to the detection of,on average,36%(7383/20663)of the total new TB cases in their respective townships(range:15-52%).Conclusion:Community-based TB care supported by INGOs successfully achieved TB case detec
Kyaw Thu SoeSaw SawJohan van GriensvenShuisen ZhouLe WinPalanivel ChinnakaliSafieh ShahMyo Myo MonSi Thu Aung
关键词:TUBERCULOSISVOLUNTEERS
China’s 1-3-7 surveillance and response strategy for malaria elimination: Is case reporting, investigation and foci response happening according to plan?被引量:21
2015年
Background:The China’s 1-3-7 strategy was initiated and extensively adopted in different types of counties(geographic regions)for reporting of malaria cases within 1 day,their confirmation and investigation within 3 days,and the appropriate public health response to prevent further transmission within 7 days.Assessing the level of compliance to the 1-3-7 strategy at the county level is a first step towards determining whether the surveillance and response strategy is happening according to plan.This study assessed if the time-bound targets of the 1-3-7 strategy were being sustained over time.Such information would be useful to improve implementation of the 1-3-7 strategy in China.Methods:This cross-sectional study involved country-wide programmatic data for the period January 1st 2013 to June 30th 2014.Data variables were extracted from the national malaria information system and included socio-demographic information,type of county,date of diagnosis,date of reporting,date of case investigation,case classification(indigenous,or imported,or unknown),focus investigation,date of reactive case detection(RACD),and date of indoor residual spraying(IRS).Summary statistics and proportions were used and comparisons between groups were assessed using the chi-square test.Level of significance was set at a P-value≤0.05.Results:Of a total of 5,688 malaria cases from 731 counties,there were 55(1%)indigenous cases(only in Type 1 and Type 2 counties)and 5,633(99%)imported cases from all types of counties.There was no delay in reporting malaria cases by type of county.In terms of case investigation,97.5%cases were investigated within 3 days with the proportion of delays(1.5%)in type 2 counties,being significantly lower than type 1 counties(4.1%).Regarding active foci,96.4%were treated by RACD and/or IRS.Conclusions:The performance of 1-3-7 strategy was encouraging but identified some challenges that if addressed can further improve implementation.
Shui-Sen ZhouShao-Sen ZhangLi ZhangAafje ECRietveldAndrew RRamsayRony ZachariahKaren BissellRafael Van den BerghZhi-Gui XiaXiao-Nong ZhouRichard ECibulskis
海南省乐东县恶性疟原虫对氯喹抗性的变化被引量:14
1999年
目的:监测海南省停用氯喹后抗氯喹恶性疟原虫对氯喹抗性的消长。方法:选择恶性疟原虫对氯喹有高度抗性且恶性疟发病率较高的海南省乐东县为观察点,采用WHO标准体外微量法和体内四周法,间隔一定时间检测一次。结果:停用氯喹18年,体外法,抗性率由1981年的97.9%下降至1997年的26.7%(P<0.001),完全抑制裂殖体形成的平均药浓度由10.46±7.14pmol/μl血降至1.63±1.47pmol/μl血(P<0.001);体内法,抗性率由1981年的84.2%降为1997年的18.4%(P<0.001),RⅢ占抗性病例的比例由53.1%降为14.3%。
刘德全蔡贤铮任道性刘瑞君刘瑞君曾林海唐铣
关键词:恶性疟原虫抗药性敏感性氯喹疟疾
云南省恶性疟原虫对氯喹、氨酚喹、哌喹、甲氟喹、奎宁敏感性的体外测定被引量:13
1999年
目的:了解云南省恶性疟原虫对氯喹、氨酚喹、哌喹、甲氟喹及奎宁的敏感性。方法:采用Rieckmann体外微量法测定采自云南省瑞丽11个县、市的恶性疟原虫对以上药物的敏感性。结果:云南省南部、东南部及西部恶性疟原虫对氯喹抗性率分别为96.7%、78.9%及95.7%,ID50依次为125nmol/L、136nmol/L、及176nmol/L;对氯酚喹的抗性率分别为100%、85.3%及88.9%,ID50依次为52nmol/L、54nmol/L及72nmol/L;对奎宁均为敏感,ID50依次为480nmol/L、352nmol/L及608nmol/L。南部及东南部原虫对哌喹的抗性率分别为68及88nmol/L;结论:云南省恶性疟原虫对4-氨基喹啉类药物普遍产生抗性,其抗性程度来自滇西及其相连的缅甸感染的疟原虫明显高于滇东南;对奎宁及甲氟喹敏感。氯喹。
杨恒林刘德全黄开国杨亚明杨亚明廖明铮杨品芳
关键词:恶性疟原虫体外测定氯喹氨酚喹
62例脑型血吸虫病病例分析被引量:1
2008年
目的:通过对脑型血吸虫病患者临床发病特征的分析,探索该病发病的相关因素和发病机制,为预防和控制该病提供科学依据。方法:对安徽省13个县(市)血防机构1997-2004年期间诊治的62例脑型血吸虫病病例进行临床发病特征分析。结果:62例脑型血吸虫病例分析显示男女性别比为2.88:1,平均年龄(33.40±10.73)岁,以农民和水上作业者居多,占75.8%。临床表现以慢性脑型血吸虫病为主,占90.32%,临床上诊断该病主要采用血清免疫学、B超和CT检查,发病部位以顶叶、额叶、颞叶常见,以单发病灶多见。单纯吡喹酮治疗与单纯手术治疗疗效无明显差异。全部病例随访,51例恢复正常生活和工作。结论:脑型血吸虫病多见于青壮年,男性多于女性,农民和水上作业者发病比例较大,发病类型以慢性脑型血吸虫病多见。影像学检查对脑型血吸虫病的诊断和分型有重要参考价值。从发病类型、病灶部位、特性探讨发病原因对该病发病机制和分型的研究有重要价值。吡喹酮治疗和手术治疗对该病均具有较好的疗效。及时准确的诊断对减轻该病的危害具有重要意义。
黄月娥汪天平张世清吕大兵操治国
关键词:脑型血吸虫病发病相关因素
氯硝柳胺控释剂药物动力学的研究被引量:8
1993年
通过对氯硝柳胺控释剂这一双层(速释层和缓释层)包衣丸剂药物动力学的研究,观察到其降解过程是按一级反应进行,并得出有关药物动力学参数,该控释剂半减期长,具有缓慢释药的长效作用。现场施药及室内流水冲洗1年、1.5年后,该制剂尚剩余药量7.62%和19.5%,其浸液仍有灭螺效果;远比常规氯硝柳胺糊剂喷洒法的理论持效时间长(9.7d),理论用药量少。不仅避免药物浪费,而且减轻环境污染和对鱼类的毒害等。结果提示:氯硝柳胺控释剂是一个研制成功的新型长效杀螺剂。
蔡德全卢永嵩左世会席金玉
关键词:氯硝柳胺控释剂药物动力学灭螺
农村晚期丝虫病人的医疗需要和需求
1999年
1994年丝虫病已在全国基本消灭,免费防治也早已停止。目前,百万丝虫病人的患病、医疗情况不太清楚。1996年对山东省登记在册的丝虫病人和丝防机构、科室进行抽样调查发现,300名病人中,63%的人1995年以来仍有丝虫病征的急性发作,仍需治疗,但他们当中60%的人没有得到必要的治疗;急需治疗者中,乳糜尿病人占69%,具有年纪较轻、女性多、痛苦和经济损失重的特点;当地的丝防机构坐等病人,社会和经济效益不佳。
袁方曙李顺平郭淑玲王兴洲刘兴柱杨宗河张学启刘开军肖龙彬
关键词:丝虫病社区卫生服务医疗保障制度
The road towards sustainable control of schistosomiasis in the Democratic Republic of Congo:Pre-assessment of staff performance and material resources in endemic regions
2017年
Objective: To improve knowledge and practice of health staff as well as the availability of material resources for diagnosis and management of schistosomiasis in two endemic provinces of DRC(Kinshasa and Bas-Congo).Methods: Structured interviews were performed using questionnaires with staff from 35 healthcare facilities in 9 health zones(HZ) of Kinshasa and 2 HZ in Bas-Congo.Results: Schistosomiasis was reported to be present in all the included HZ.Health staff knew the most important symptoms of schistosomiasis, but advanced symptoms were more accurately reported in Bas-Congo.Knowledge of symptoms related to schistosomiasis such as anemia(P = 0.0 115) and pollakiuria(P = 0.0 260) was statistically different in both two provinces.Kato-Katz technique and urine filtration were unavailable in both provinces.Parasitological diagnosis was mostly performed using the direct smear method.PZQ was available in 70% of the health facilities, all situated in Bas-Congo.Diagnosis and treatment mostly relied on symptoms and cost more in urban area than in rural.Conclusions: Though knowledge on schistosomiasis among health staff appears sufficient, substantial efforts still must be made to improve the availability of diagnostic tools and treatment in the health facilities in DRC.
Sylvie LinsukeLiliane MpabanziSabin NunduFaustin MukundaPascal LutumbaKatja Polman
关键词:SCHISTOSOMIASISCONTROLRESOURCES
日本血吸虫病肝脏超声显像分析被引量:2
2005年
目的提出日本血吸虫病肝脏超声显像肝实质图像的分类。方法利用原研究课题曾在洞庭湖的华容、汉寿、澧县中度流行区3个临湖自然村的居民及同期在本院住院的晚期血吸虫病人超声显像检查图像中的2918例肝脏图片,进行分类分型。结果肝实质图像有光点正常91例、增粗1757例、光斑121例、光条467例、光带482例等5类。其形状有光点正常91例、增粗1757例、光片59例、光斑62例、细条323例、粗条144例、细带280例、粗带202例等8型。结论超声显像诊断日本血吸虫病图像可分为5类8型。
黄令霞邓维成孙可英李俊汪郁罗凤球
关键词:日本血吸虫病超声显像
Assessment of household ownership of bed nets in areas with and without artemisinin resistance containment measures in Myanmar被引量:1
2018年
Background:Myanmar lies in the Greater Mekong Subregion where there is artemisinin-resistant Plasmodium falciparum malaria.As the artemisinin compound is the pillar of effective antimalarial therapies,containing the spread of artemisinin resistance is a national and global priority.The use of insecticide-treated bed nets/long-lasting insecticidal nets(ITNs/LLINs)is the key intervention for ensuring the reduction of malaria transmission and the spread of resistant strains,and for eventually eliminating malaria.This study aimed at assessing household ownership of,access to,and utilization of bed nets in areas of Myanmar with and without artemisinin resistance containment measures.Methods:Secondary data from a nationwide community-based malaria survey conducted by the National Malaria Control Program in 2014 were analyzed.Based on evidence of artemisinin resistance,Myanmar was divided into tiers 1,2,and 3:townships in tiers 1 and 2 were aggregated as the Myanmar Artemisinin Resistance Containment(MARC)areas and were compared with tier 3 townships,which were defined as non-MARC areas.The chi-square test was used to compare groups,and the level of significance was set at P≤0.05.Results:Of the 6328 households assessed,97.2%in both MARC and non-MARC areas had at least one bed net(any type),but only 63%of households had ITNs/LLINs.Only 44%of households in MARC areas and 24%in non-MARC areas had adequate numbers of ITNs/LLINs(one ITN/LLIN per two persons,P<0.001).Nearly 44%of household members had access to ITNs/LLINs.Regarding the utilization of ITNs/LLINs,45%of household members used them in MARC areas and 36%used them in non-MARC areas(P<0.001,desired target=100%).Utilization of ITNs/LLINs among children aged below five years and pregnant women(high malaria risk groups)was low,at 44%and 42%,respectively.Conclusions:This study highlights the nationwide shortfalls in the ownership of,access to,and utilization of ITNs/LLINs in Myanmar,which is of particular concern in terms of containing the spread of artemisinin resist
Thae Maung MaungTin OoKhin Thet WaiThaung HlaingPhilip OwitiBinay KumarHemant Deepak ShewadeRony ZachariahAung Thi
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