lschemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells （hUC-MSCs） has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique ＂immunosuppressive and immunoprivilege＂ property, hUC-MSCs are advised to be an important candidate for aUogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
目的:探究肾脑复元汤对MCAO大鼠脑保护作用及其机制。方法:72只SD大鼠随机分为假手术组、模型组、肾脑复元汤组,根据处死时间每组再随机分为3 d、7 d、14 d 3个亚组。比较各组大鼠神经功能缺损评分、脑梗死体积、神经营养因子HGF及TGF-β表达。结果:与模型组比较,肾脑复元汤组大鼠神经功能缺损评分明显下降(P<0.01),脑梗死体积明显缩小(P<0.01),缺血侧脑组织HGF及TGF-β表达明显增加(P<0.01)。结论:肾脑复元汤可以明显改善MCAO大鼠神经功能缺损症状,并促进脑梗死组织修复,其机制可能是通过促进HGF、TGF-β的表达。
