This paper studied the spot welding structure of ultra-high strength steel 22MnB5.ANSYS software was adopted to simulate its static strength;BS5400 algorithm was used to calculate the fatigue life;and the grouping method was used to test the fatigue performance of tensile shear spot weld specimens.The simulation results were in good agreement with the experimental values.Based on the validation of the simulation method,influences of different structural parameters on static strength and fatigue life were explored by adopting single factor.The results showed that within the selected structure parameter range,increase of the sheet thickness,nugget diameter,sheet width and overlapping length can lead to longer fatigue life.Besides,the fatigue life of spot weld took on a linear relationship with the overlapping length,a DoseResp relationship with the sheet thickness,and a single exponential decay relationship with the sheet width and the nugget diameter.Moreover,in order to estimate the impact from various parameters on the fatigue life of the specimens,the Taguchi orthogonal design method was applied in the simulation design.The simulating result indicated that influence of the sheet thickness on fatigue life was the most significant.In addition,the effects of nugget diameter,sheet width and overlapping length on fatigue life were reduced in turn.