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Involvement of the insulin signaling in DNA synthesis of silk gland cells in the silkworm, Bombyx mori: The insulin signal pathway plays an important role in regulating cell growth and cell proliferation. The purpo...; LI Yao-FengCHEN Xiang-YunTANG Xiao-FangWANG LaZHANG Chun-DongPAN Min-HuiLU Cheng; 关键词：SILK GLAND DNA INSULIN; 文献传递

Differential susceptibilities to Bm NPV infection of two cell lines derived from the same silkworm ovarian tissues: We previously established and characterized two insect cell lines(BmN-SWU1 and BmN-SWU2) from Bombyx mori ovar...; ZHANG JunCHEN Xue-MeiZHANG Chun-DongHE QianDONG Zhan-QiCAO Ming-YaDONG Xiao-LongLU ChengPAN Min-Hui; 关键词：SILKWORM NUCLEOPOLYHEDROVIRUS VIRAL VIRAL; 文献传递

ROS-mediated oxidative stress induced apoptosis in Bm N-SWU1 cells via the mitochondrial apoptotic pathway: Oxidative stress plays a key role in the regulation and control of cell survival. Reactive oxygen species(ROS)...; HU Yan-FenPAN ChunSONG JuanYI Hua-ShanCHEN Xiang-YunWANG LaPAN Min-HuiLU Cheng; 关键词：MITOCHONDRIA REACTIVE CELLS; 文献传递

39k Promoter is an Inductive Bombyx mori nucleopolyhedrovirus Promoter with High Efficiency: Bm NPV is the most representative virus among baculovirus, which possesses the homology for about 80%with Ac M...; Cao Ming-YaKuang Xiu-XiuZhang JunHe QianLi Hai-QingXiao Wen-FuDong Zhan-QiLu ChengPan Min Hui; 关键词：BACULOVIRUS BMNPV PROMOTER; 文献传递

Microarray analysis of differentially expressed genes in Bombyx mori Ovary, two silkworm cell lines and their pre-/post-infection stage: The silkworm is an important economic insect and the viral disease, especially nucleopolyhedrovirus,results in...; DONG Xiao-LongWANG Ting-TingLIU Tai-HangWANG WeiPAN Cai-XiaZHANG JunCHEN PengLU ChengPAN Min-Hui; 关键词：NUCLEOPOLYHEDROVIRUS; 文献传递

Characterization of late gene expression factor LEF-11 form Bombyx mori nucleopolyhedrovirus: Baculovirus late expression factors(LEFs) are involved in viral DNA replication and viral gene regulation. Bac...; DONG Zhan-QiZHANG JunHE QianCAO Ming-YaHU NanCHEN Ting-TingLU ChengPAN Min-Hui; 关键词：BMNPV REPLICATION PP2A; 文献传递

The silkworm GSTe4 is sensitive to phoxim and plays a role in inhibition of apoptosis: Glutathione S-transferases(GSTs, EC 2.5.1.18) are a family of super enzymes with multiple functions,and play a...; CHEN Xiang-YunLIU JiaZHANG Chun-DongLI Yao-FengLIU Tai-HangHU Yan-FenYU Quan-YouZHANG You-HongLU ChengPAN Min-Hui; 关键词：GLUTATHIONE S-TRANSFERASE PHOXIM APOPTOSIS; 文献传递

Effects of starvation and hormones on DNA synthesis in silk gland cells of the silkworm, Bombyx mori: Silk gland cells of silkworm larvae undergo multiple endomitotic cell cycles for the synthesis of silk protein...; LI Yao-FengCHEN Xiang-YunZHANG Chun-DongTANG Xiao-FangWANG LaLIU Tai-HangPAN Min-HuiLU Cheng; 关键词：ENDOMITOSIS GLAND STARVATION 20-HYDROXYECDYSONE; 文献传递

BmCyclin B和BmCyclin B3是家蚕细胞周期进程所必需的被引量：5: 2013年; B型细胞周期蛋白(Cyclin B)是细胞G2期向M期转化的重要调节因子.家蚕基因组数据分析表明,家蚕有2个Cyclin B基因,即BmCyclin B和BmCyclin B3.利用家蚕EST数据,成功克隆了家蚕CyclinB3基因(EU074796),该基因全长1665bp,ORF长1536bp,由6个内含子和7个外显子构成,编码511个氨基酸,含有1个蛋白破坏盒和2个周期蛋白盒,预测分子量57.8kD.家蚕卵巢细胞系BmN-SWU1的BmCyclinB和BmCyclinB3基因RNA干涉结果表明,BmCyclin B和BmCyclin B3是家蚕细胞完成细胞周期进程所必需的,二者干涉后均能导致细胞周期阻滞于G2/M期,抑制细胞的增殖.; 潘敏慧洪开丽陈向云潘春陈雪梅匡秀秀鲁成; 关键词：家蚕细胞周期细胞增殖

BmCyclin B and BmCyclin B3 are required for cell cycle progression in the silkworm, Bombyx mori被引量：2: 2013年; Cyclin B is an important regulator of the cell cycle G2 to M phase transition. The silkworm genomic database shows that there are two Cyclin B genes in the silkworm (Bombyx mori), BmCyclin B and BmCyclin B3. Using silkworm EST data, the cyclin B3 (EU074796) gene was cloned. Its complete cDNA was 1665 bp with an ORF of 1536 bp derived from seven exons and six introns. The BmCyclin B3 gene encodes 511 amino acids, and the predicted molecular weight is 57.8 kD with an isoelectric point of 9.18. The protein contains one protein damage box and two cyclin boxes. RNA interference-mediated reduction of BmCyclin B and BmCyclin B3 expression induced cell cycle arrest in G2 or M phase in BmN-SWU1 cells, thus inhibiting cell proliferation. These results suggest that BmCyclin B and BmCyclin B3 are necessary for completing the cell cycle in silkworm cells.; PAN MinHuiHONG KaiLiCHEN XiangYunPAN ChunCHEN XueMeiKUANG XiuXiuLU Cheng

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国家自然科学基金(31272505)