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小鼠匹鲁卡品癫痫模型潜伏期CA3区后放电阈值及脑电频谱能量的变化: 目的匹鲁卡品(pilocarpine)癫痫模型的潜伏期被认为是其癫痫自发的形成过程。本实验采用小鼠匹鲁卡品模型,研究潜伏期内电刺激诱导的后放电阈值(A DT)以及脑电(EEG)频谱能量的变化。方法ICR小鼠立体定位在右侧...; 徐层林许正浩陈忠; 关键词：匹鲁卡品癫痫模型潜伏期

Low frequency stimulation of entorhinal cortex inhibits hippocampal neuronal activities and fast kindling seizures: Objective The entorhinal cortex(EC) is a potential target for low frequency stimulation(LFS,1Hz)treatment of t...; Zheng-hao XUYi WANGAn-Feng TAOCeng-Lin XUMiao-Miao JINKai ZHONGShi-Hong ZHANGZhong CHEN; 关键词：EPILEPSY KINDLING

酸后处理对脑缺血再灌注损伤的保护作用: 目的探讨酸后处理,即在再灌早期给予一段短时间的酸化处理,是否对脑缺血再灌注损伤具有保护作用.方法本实验采用小鼠大脑中动脉栓塞(MCAO)模型和大鼠皮质原代神经元氧糖剥夺(OGD)模型.在再灌早期不同时间点吸入含有20...; 沈哲范彦英张翔南陈忠; 关键词：缺血再灌注损伤

The crucial period for focal low frequency stimulation inhibiting the development of amygdala-kindling in rats: Objective To investigate whether there is a crucial period for focal low frequency stimulation(LFS) inhibiting...; Yi WANG,Zheng-Hao XU,Yang LIU,Kai ZHONG,Ceng-Lin XU,Wei-Wei HOU,Shi-Hong ZHANG,Zhong CHEN~* Institute of Neuroscience,Department of Pharmacology,College of Pharmaceutical Sciences,School of Medicine, Zhejiang University,Hangzhou 310058,China; 关键词：EPILEPSY

疏水性分形材料PPP对星形胶质细胞的生长与分化的影响: 目的星形胶质细胞对于维持脑功能有着重要作用,它在体内的作用与它的立体结构密切相关.而传统的体外培养的星形胶质细胞失去了它典型的多突触星形状,呈现出扁平的形态.本实验采用由三棕榈酸甘油酯(PPP)合成的具有斥水性的分形材...; 王喆胡薇薇陈忠; 关键词：星形胶质细胞 PPP 原代培养疏水性

Multiple role of minocycline in chronic ischemic cerebral white matter injury: OBJECTIVE The aim of this study was to investi- gate the protection of minocycline in chronic ischemic cerebra...; 马婧

Effect of histaminergic system on brain ischemia: Ischemic stroke is a disease with high mortality and a main leading cause of disability.However,few effective ...; 袁杨

Histamine modulation of acute nociception involves regulation of Nav1.8 in primary afferent neurons in mice: OBJECTIVE To explore the role of histamine in acute pain perception.METHODS We studied the sensitivity to acut...; 于捷Hiroshi Ohtsu

Astrocytes cultured on water-repellent fractal tripalmitin surface demonstrate superior morphology and functions compared with traditional culture substrate: Objective In the CNS,astrocytes play an essential role with their multiple functions and sophisticated structu...; Zhe WANGWei-Wei HUBi-Yuan HONGShan-Shan ZHANGWen-Yun FANGZhong CHEN; 关键词：ASTROCYTE FRACTAL TRIPALMITIN

肌肽在血管性痴呆治疗中的应用及研究进展被引量：3: 2015年; 血管性痴呆是临床发病率排在第二位的认知障碍性疾病,以白质损伤引起的认知功能障碍和胶质细胞的激活为主要病理表现。目前临床上药物治疗疗效有限,且不能有效逆转损伤、减缓疾病的进程,因此,对新药物的研发存在迫切的需求。肌肽(β-丙氨酰-L-组氨酸)是由β-丙氨酸和L-组氨酸两种氨基酸组成的天然二肽,能够由外周进入神经中枢系统,转变成组氨酸后成为组胺,是体内组胺的天然储存库,对急性脑缺血损伤发挥保护作用。近年研究发现肌肽对血管性痴呆的保护作用不是通过肌肽-组氨酸-组胺的途径,而是通过抑制兴奋性氨基酸毒性、氧自由基的产生、胶质细胞的激活以及髓鞘的退化发挥保护作用,由此证明肌肽对于血管性痴呆有着潜在的临床治疗作用。本文针对肌肽对血管性痴呆治疗的研究进展进行综述。; 马婧陈婷张金莲徐阿晶刘艳; 关键词：肌肽血管性痴呆氧自由基组胺

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