A novel bifunctional glycolipid which carried a cluster of thiogalactosides as the hepatocyte targeting ligand for gene delivery was prepared. Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly(ethylene glycol) chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce penta- antennary galactoside. Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.
Qing Lin Jiang Li Hai Lei Chen Jiao Lu Zhi Rong Zhang Yong Wu
A novel bifunctional compound carrying cluster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain. This design provided an effective entry for the synthesis of the bifunctional compound.
Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang Jin Cheng Yang Li Hai
