Common tools based on landmarks in medical image elastic registration are Thin Plate Spline (TPS) and Compact Support Radial Basis Function (CSRBF). TPS forces the corresponding landmarks to exactly match each other and minimizes the bending energy of the whole image. However, in real application, such scheme would deform the image globally when deformation is only local. CSRBF needs manually determine the support size, although its deformation is limited local. Therefore, to limit the effect of the deformation, new Compact Support Thin Plate Spline algorithm (CSTPS) is approached, analyzed and applied. Such new approach gains optimal mutual information, which shows its registration result satisfactory. The experiments also show it can apply in both local and global elastic registration.
