Bombyx mori bidensovirus(BmBDV),which had been assigned to Densovirinae in Parvoviridae previously,replicates mainly in silkworm midgut columnar cells and causes the fatal flacheric disease.In contrast to parvovirus,this virus possesses two single-stranded DNA genome segments and encodes a putative protein-primed DNA polymerase.The accumulating evidence suggests that it has unique characteristics different to parvovirus and adopts its own mechanisms for replication.So far,little is known about the replication mechanisms of BmBDV.In this review,we focus on the pathology associated with this virus and the viral biology such as viral genome structure,viral genes,and viral replication and expression strategies.
HU ZhaoYangLI GuoHuiLI GuangTianYAO QinCHEN KePing
细小病毒编码的非结构蛋白NS1(non-structural protein 1)是一种多功能蛋白,该蛋白质与病毒DNA的复制、基因转录调控、诱导细胞病理变化等密切相关。本文对细小病毒NS1蛋白的基因转录激活功能、磷酸化修饰以及与胞内蛋白的相互作用等研究进展进行综述,为研究家蚕双义病毒(BmBDV)的NS1蛋白作用机制提供参考。
