AIMS To increase the discovering rate of early gastric cancer and the positive rate of biopsy,the brilliant blue(BB)chromo-en- doscopy and the routine endoscopy were used to examine 54 pa- tients with gastric cancer. METHODS BB staining method and steps:Othe examinee was injected IM 20 mg of Anisodamini Hydromidum;②he took a cup of BB solution;③after 40-60 min he was examined with the endoscope.All of the examinee were also examined with the rou- tine endoscope. RESULTS Sixteen of 54 patients were demonstrated to suffer from early gastric cancer,the detecting rate of early cancer being 29.4%.Among these,15 cases were discovered by BB endoscopy,and only 5 cases by the routine endoscopy.The for- mer is more sensitive in discovering early gastric cancer than the latter(P<0.01)o In addition,the BB endoscopy increases the positive rate of biopsy from 70.4%(38/54)to 94.4%(51. 54),which is clearly supperior in the diagnosis of gastric can- cer to that by routine endoscopy(P<0.01). CONCLUSIONS The BB chromo-endoscopy is more useful in following up the gastric precancerous lesion than the routine endoscopy.