Sema3F是一种在多种神经类疾病中起重要作用的信号素,其在神经元内的受体研究对于治疗这类疾病具有潜在的临床意义。文章重点探讨了Sema3F通过其全受体复合物,包括神经纤毛蛋白-2 (Neuropilin-2, NRP2)和丛蛋白A3 (PlexinA3)来传递信号,并参与引导神经元以及调节免疫反应、炎症和宿主防御。研究还发现Sema3F与NRP-2的结合亲和力高于NRP-1,且Sema3家族成员需要通过弗林蛋白酶的水解加工才能与NRP1竞争性结合,揭示了Sema3活性的新型调节机制。这些发现对于理解Sema3F在神经系统中的作用及其在疾病治疗中的潜在应用具有重要意义。Sema3F is a signaling that plays an important role in a variety of neurological diseases. The study of its receptor in the menstrual cells has potential clinical significance for the treatment of such diseases. The paper focuses on Sema3F to transmit signals through its full receptor complex, including Neurofibromalin-2, NRP2, and plexinA3 and is involved in guiding neurons as well as regulating immune response, inflammation, and host defense. The study also found that Sema3F has a higher binding affinity with NRP-2 than NRP-1 and that members of the Sema3 family need to be hydrolyzed by Flynne enzyme to competitively bind to NRP1, revealing a novel regulatory mechanism of Sema3 activity. These findings have important implications for understanding the role of Sema3F in the nervous system and its potential use in disease therapy.
