Sema3F是一种在多种神经类疾病中起重要作用的信号素,其在神经元内的受体研究对于治疗这类疾病具有潜在的临床意义。文章重点探讨了Sema3F通过其全受体复合物,包括神经纤毛蛋白-2 (Neuropilin-2, NRP2)和丛蛋白A3 (PlexinA3)来传递信号,并参与引导神经元以及调节免疫反应、炎症和宿主防御。研究还发现Sema3F与NRP-2的结合亲和力高于NRP-1,且Sema3家族成员需要通过弗林蛋白酶的水解加工才能与NRP1竞争性结合,揭示了Sema3活性的新型调节机制。这些发现对于理解Sema3F在神经系统中的作用及其在疾病治疗中的潜在应用具有重要意义。Sema3F is a signaling that plays an important role in a variety of neurological diseases. The study of its receptor in the menstrual cells has potential clinical significance for the treatment of such diseases. The paper focuses on Sema3F to transmit signals through its full receptor complex, including Neurofibromalin-2, NRP2, and plexinA3 and is involved in guiding neurons as well as regulating immune response, inflammation, and host defense. The study also found that Sema3F has a higher binding affinity with NRP-2 than NRP-1 and that members of the Sema3 family need to be hydrolyzed by Flynne enzyme to competitively bind to NRP1, revealing a novel regulatory mechanism of Sema3 activity. These findings have important implications for understanding the role of Sema3F in the nervous system and its potential use in disease therapy.
信号素(Semaphorin)作为一组多功能的蛋白质,占据神经系统功能发育的关键,包括对调节突触形成和神经元的生长的同时,还参与调控细胞周期、影响细胞形态的转变,以及在肿瘤学中,它们能够影响肿瘤细胞的生长、侵袭和转移,以及在免疫反应中发挥作用。信号素(Semaphorin, SEMA)是一类分泌型、膜结合型或糖磷脂酰肌醇锚定的糖蛋白,与神经发育、轴突引导、骨分化、心血管系统以及癌症等相关。Sema3F (Semaphorin 3F)是信号素家族轴突引导分子的一种分泌型,参与神经元的发育。Sema3F及其受体神经纤毛蛋白-2在胚胎小鼠大脑区域(包括嗅球、海马体和大脑皮层)中以互斥方式表达。Sema3F作用在神经元上,可引起下游因子的改变,包括CREBBP、CREB、VEGF等,能够下调P53表达、影响GABA能系统、下调RacGTP水平、促进CRMP2磷酸化等。本文通过综述的方法,对Sema3F在神经元下游因子进行叙述,为研究Sema3F在神经元中的功能提供帮助。Semaphorin, as a group of multifunctional proteins, plays a crucial role in the functional development of the nervous system. It not only regulates synapse formation and the growth of neurons but also participates in the regulation of the cell cycle, influences the transformation of cell morphology. Moreover, in oncology, it can affect the growth, invasion and metastasis of tumor cells and also plays a role in immune responses. Semaphorin (SEMA) is a type of secreted, membrane-bound or glycosylphosphatidylinositol-anchored glycoprotein, which is related to neural development, axon guidance, bone differentiation, the cardiovascular system and cancer, etc. Sema3F, a secreted form of the axon guidance molecules in the Semaphorin family, is involved in the development of neurons. Sema3F and its receptor neuropilin-2 are expressed in a mutually exclusive manner in the brain regions (including the olfactory bulb, hippocampus and cerebral cortex) of embryonic mice. When Sema3F ac
