Room temperature operation is an important criterion for high performance of quantum cascade lasers. A strain-compensated quantum cascade laser(λ≈5.5μm) with optimized waveguide structure lasing at room temperature is reported. Accurate control of layer thickness and strain-compensated material composition is demonstrated using X-ray diffraction. An output power of at least 45mW per facet is realized for a 20μm-wide and 2mm-long laser at room temperature.