There are increasing evidences that the primary caustal factor for the development of most dibetic complications is prolonged exposure to hyperglycemia. One of the major pathophysiological con sequences of hyperglycemia is that the chemical interaction of glucose with proteins forms advanced glycosyla glycosylation end- products (AGEs), which may account for numemes features of diabetic complications and aging.In the review,the structural aspets, direct and indirect pathogenic significance of AGEs,clinical considera tions,the relationship of AGEs with aging (espeially Alzheimer’s disease), inhibition of AGEs formation and its achvity were discussed.
