尿酸是嘌呤代谢的终产物,血浓度超过一定阈值会导致躯体疼痛、功能受损。目前认为高尿酸血症与心血管疾病、代谢综合征、卒中、肾脏疾病等密切相关,然而尿酸与各类疾病的关系、尿酸是否是这些疾病的独立危险因素的结论尚未达成共识。本文就尿酸与心血管疾病、肾脏疾病、癌症、糖尿病、神经系统疾病的关系进行综述。Uric acid is the end product ofpurine metabolism. It will cause physical pain and impaired function when theblood concentration exceeds a certain threshold. It is acknowledged thathyperuricemia is related to cardiovascular disease, metabolic syndrome, strokeand kidney disease. However, there is no consensus on the relationship betweenuric acid and different diseases and whether uric acid is an independent riskfactor of these diseases. This article reviews the relationship between uric acid and cardiovascular disease, kidney disease,cancer, diabetes, and nervous system disease.
