c-Jun氨基末端激酶（c-Jun N-terminal kinase,JNK）家族是1990年被发现的丝裂原活化蛋白激酶（mito-gen-activated protein kinase,MAPK）超家族成员之一,涉及多种生理过程,在细胞分化、细胞凋亡、应激反应中起着至关重要的作用。JNK也参与了许多病理过程，可能介导了病理性心脏肥大反应、高血糖引起的血管内皮细胞凋亡、胰岛素抵抗、胰岛β细胞凋亡、神经萎缩和多种人类肿瘤的发生发展。JNK信号通路已成为近年来研究的热点。
Perceptual learning of orientation discrimination was investigated using cats. Two adult cats （Cat 1 and 2） were trained to monocularly discriminate between two static striped sinusoidal grates with 30° orientation difference. After greater than 80% correct performance was reached, cats were then required to monocularly perform a discrimination between two grates with consecutively shifting orientation difference（2°, 4°, 6°, 8°, 10°, 12°, 16°, 20°, 24°, 30°） . The staircase method （two correct-down and one error-up） was applied throughout the training to track the threshold of orientation difference that cats could detect. The performance of detecting grates with varied orientation difference was measured respectively for beth trained and untrained eyes before and after training. Our results showed that the learning effect of discrimination for grates with a fixed orientation difference transferred completely from the trained eye to the untrained eye, whereas the inter-eye transfer for detecting °ates with gradually reducing orientation difference was almost nonegrates. The two opposite learning effects in the same subject strongly suggest that different information processing mechanisms might mediate the learning processes.
