seventeen cases of juvenile laryngeal papilloma were investigated for human papiliomavirus (HPV) using in situDNA hybridisation to determine the HPV infection in the disease in Guangdong Chinese . The results showedthat ten of seventeen cases were positive forHPV-DNA, countering for 58.8%, while the controlwas negative(P<0.005). this implies that the HPV infection is reponsible for the development of the disease inGuangdong area. The authours believe that it is necessaryto classify the disease into two types: juvenile laryngealpaillomas with and without HPV infection,. afterconsidering the history of their parents’ condylomaaccuminatum , the age of onset, the recurrence after treatment, the morphologic feature and the evidence of HPVinfection including the HPA subtypes which is the mostimportant of all.
