功能性消化不良(functional dyspepsia, FD)是临床常见的功能性胃肠疾病之一,基于中医理论认为脑肠之间以经络相通、神明共统且生理病理紧密联系。中医药能够通过脑肠轴(brain-gut axis, BGA)对脑肠肽(brain-gut peptide, BGP)进行影响,从而促进胃肠道蠕动,加速胃排空,降低内脏高敏性、调节肠道菌群等,有效遏制FD进展。脑肠轴失调造成的脑肠肽水平紊乱是FD的重要特征之一。因此,本文就中医药通过调节脑肠轴治疗FD进行综述,以期为临床治疗提供新策略及思路。Functional dyspepsia (FD) is one of the common clinical functional gastrointestinal diseases. Based on the theory of traditional Chinese medicine, it is believed that the brain and intestine are closely connected with the meridians, the spirit and the physiology and pathology. Traditional Chinese medicine can effectively inhibit the progression of FD by influencing brain-gut peptide (BGP) through brain-gut axis (BGA), thereby promoting gastrointestinal peristalsis, accelerating gastric emptying, reducing visceral hypersensitivity, and regulating intestinal flora. The disturbance of brain-gut peptide level caused by brain-gut axis disorder is one of the important features of FD. Therefore, this article reviews the treatment of FD by regulating the cerebro-intestinal axis of traditional Chinese medicine, in order to provide new strategies and ideas for clinical treatment.
目的:观察养肝消脂茶治疗非酒精性脂肪肝(NAFLD)的疗效。方法:选取2018年1月—2019年12月在我院进行救治的NAFID患者50例(NAFLD组)与50名健康人(正常组)对照作为研究对象。两组均进行常规体检和肝脏超声检查和弹性剪切波测量,以剪切波速度值作为疗效评价指标。N A F L D组患者服用养肝消脂茶12周,检测治疗前后血清生化指标和剪切波速度值的变化,对比分析两组一般指标、疗效指标、影像学指标等。结果:治疗前NAFLD组血清ALT、TG较正常组明显升高,剪切波速度值较正常组明显增高(P<0.01),服用养肝消脂茶治疗后NAFLD组ALT、TG均明显下降,剪切波速度值也降低(P<0.05)。结论:养肝消脂茶治疗NAFLD疗效肯定。
