三叉神经痛(trigeminal neuralgia)是临床上的顽疾,长期以来为医学界所重视,但其发病机制尚不清晰,临床上也无有效的治疗方法。本研究首先通过免疫荧光化学法和动物行为学测定,对经眶下孔达三叉神经节目标注射给药法的效果进行了评价,然后行眶下神经慢性缩窄环术(chronic constriction injury of the infraorbital nerve,ION-CCI)建立三叉神经病理性痛大鼠模型,用经眶下孔达三叉神经节目标注射法分别注射BKCa通道激动剂NS1619和Kv通道拮抗剂4-AP,观察药物对大鼠面部机械痛阈的影响。结果显示,通过经眶下孔达三叉神经节目标注射法,药物可以准确到达三叉神经节,并产生了比一般眶下孔注射给药法更为持久的注射效果。ION-CCI术后第6天大鼠术侧面部触须垫部产生了显著的异常性疼痛(allodynia),并可以维持到至少术后第42天。在ION-CCI术后第15天大鼠,运用经眶下孔达三叉神经节目标注射法注射BKCa通道激动剂NS1619可以剂量依赖性地显著提高ION-CCI组大鼠的面部机械痛阈,逆转面部痛觉过敏;而在ION-CCI术后第35天痛阈部分恢复的大鼠,同样方法注射Kv通道拮抗剂4-AP又可以显著降低面部痛阈。以上结果表明,BKCa通道激动剂NS1619和Kv通道拮抗剂4-AP可以显著影响ION-CCI大鼠的面部机械痛阈,提示激活BKCa通道可以抑制由ION-CCI引起的三叉神经病理性痛,而激活Kv通道可能对ION-CCI引起的三叉神经病理痛有紧张性的抑制作用。
为了解决应急机动测控中的信息保障问题,本文提出了一种利用无人机搭载卫星转发天线的方式,实现测控设备与专用网之间的中继通信,可将专用网覆盖范围在原有基础上向外延伸一定范围,以支持机动测控装备在原本没有专用网覆盖的区域完成测控任务。分析结果表明,采用该方法可将专用网覆盖范围向外延伸70 km以上,并可实现带宽独享,满足宽带高速数据传输需要。In order to solve the problem of information support in emergency mobile TT&C, a method of using UAV to carry satellite repeater antennae is proposed to achieve relay communication between TT&C equipment and the space business network, which can extend the coverage of the space business network to a certain extent on the original basis, so as to support mobile TT&C equipment to complete TT&C tasks in areas that were not covered by space business network. The analysis results show that this method can extend the coverage of the space business network to more than 70 km, and can achieve exclusive bandwidth to meet the needs of broadband high-speed data transmission.
