Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.
Man HuangLizhang LiuXiaoxia LiYu ShiHuimin ZhangTing LuYoujun Feng
