搜索到3155篇“ TRAFFICKING“的相关文章
Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia
2025年
Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extremities.HSP is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.
Zhenyu ChenXue-Jun Li
关键词:DEGENERATIONDISEASESHEREDITARY
Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation
2025年
Cell adhesion plays pivotal roles in the morphogenesis of multicellular organisms.Epithelial cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.
Shiho ItoTakeshi Kawauchi
关键词:CEREBRALSKELETALCOOPERATION
Unveiling Global Human Trafficking Trends: A Comprehensive Analysis
2024年
This paper presents a comprehensive analysis of global human trafficking trends over a twenty-year period, leveraging a robust dataset from the Counter Trafficking Data Collaborative (CTDC). The study unfolds in a systematic manner, beginning with a detailed data collection phase, where ethical and legal standards for data usage and privacy are strictly observed. Following collection, the data undergoes a rigorous preprocessing stage, involving cleaning, integration, transformation, and normalization to ensure accuracy and consistency for analysis. The analytical phase employs time-series analysis to delineate historical trends and utilizes predictive modeling to forecast future trajectories of human trafficking using the advanced analytical capabilities of Power BI. A comparative analysis across regions—Africa, the Americas, Asia, and Europe—is conducted to identify and visualize the distribution of human trafficking, dissecting the data by victim demographics, types of exploitation, and duration of victimization. The findings of this study not only offer a descriptive and predictive outlook on trafficking patterns but also provide insights into the regional nuances that influence these trends. The article underscores the prevalence and persistence of human trafficking, identifies factors contributing to its evolution, and discusses the implications for policy and law enforcement. By integrating a methodological approach with quantitative analysis, this research contributes to the strategic planning and resource allocation for combating human trafficking. It highlights the necessity for continued research and international cooperation to effectively address and mitigate this global issue. The implications of this research are significant, offering actionable insights for policymakers, law enforcement, and advocates in the ongoing battle against human trafficking.
Somtobe OlisahClement OdoohOghenekome EfijemueEchezona ObunadikeJane OnwuchekwaOmoshola OwolabiSaheed AkintayoCallistus Obunadike
Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology
2024年
A definitive understanding of the interplay between protein binding/migration and membrane curvature evolution is emerging but needs further study.The mechanisms defining such phenomena are critical to intracellular transport and trafficking of proteins.Among trafficking modalities,exosomes have drawn attention in cancer research as these nano-sized naturally occurring vehicles are implicated in intercellular communication in the tumor microenvironment,suppressing anti-tumor immunity and preparing the metastatic niche for progression.A significant question in the field is how the release and composition of tumor exosomes are regulated.In this perspective article,we explore how physical factors such as geometry and tissue mechanics regulate cell cortical tension to influence exosome production by co-opting the biophysics as well as the signaling dynamics of intracellular trafficking pathways and how these exosomes contribute to the suppression of anti-tumor immunity and promote metastasis.We describe a multiscale modeling approach whose impact goes beyond the fundamental investigation of specific cellular processes toward actual clinical translation.Exosomal mechanisms are critical to developing and approving liquid biopsy technologies,poised to transform future non-invasive,longitudinal profiling of evolving tumors and resistance to cancer therapies to bring us one step closer to the promise of personalized medicine.
Kshitiz PariharSeung-Hyun BKoRyan P.BradleyPhillip TaylorN.RamakrishnanTobias BaumgartWei GuoValerie M.WeaverPaul A.JanmeyRavi Radhakrishnan
关键词:TRAFFICKINGONCOLOGY
Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution
2024年
The phytohormone auxin,and its directional transport through tissues,plays a fundamental role in the development of higher plants.This polar auxin transport predominantly relies on PIN-FORMED(PIN)auxin exporters.Hence,PIN polarization is crucial for development,but its evolution during the rise of morpho-logical complexity in land plants remains unclear.Here,we performed a cross-species investigation by observing the trafficking and localization of endogenous and exogenous PINs in two bryophytes,Physco-mitrium patens and Marchantia polymorpha,and in theflowering plant Arabidopsis thaliana.We confirmed that the GFP fusion did not compromise the auxin export function of all examined PINs by using a radioac-tive auxin export assay and by observing the phenotypic changes in transgenic bryophytes.Endogenous PINs polarize tofilamentous apices,while exogenous Arabidopsis PINs distribute symmetrically on the membrane in both bryophytes.In the Arabidopsis root epidermis,bryophytic PINs have no defined polarity.Pharmacological interference revealed a strong cytoskeletal dependence of bryophytic but not Arabidopsis PIN polarization.The divergence of PIN polarization and trafficking is also observed within the bryophyte clade and between tissues of individual species.These results collectively reveal the divergence of PIN traf-ficking and polarity mechanisms throughout land plant evolution and the co-evolution of PIN sequence-based and cell-based polarity mechanisms.
Han TangKuan-Ju LuYuZhou ZhangYou-Liang ChengShih-Long TuJiri Friml
关键词:ARABIDOPSISMARCHANTIAPINSPOLARIZATION
网络贩毒案件侦查中的思维定势研究被引量:1
2024年
网络贩毒犯罪依托互联网新技术,隐蔽性、组织性、广域性日益强化,涉案毒品类型不断增多,犯罪形势日益猖獗。网络贩毒案件中侦查主体与反侦查主体思维定势具有产生基础的一致性和思维定势类型的差异性。通过充分利用犯罪行为人的思维定势,兼顾技术与经验,强化侦查协作以及大数据相关性思维,促进侦查主体与反侦查主体思维定势的功效转化,从而有利于网络贩毒案件中侦查主体进行正确的侦查途径选择,提高侦查效益。
牛承义周云怡乔顺利
关键词:思维定势侦查主体
藻类和陆生植物中光合产物的运输对光合作用的调控机制被引量:1
2024年
光合生物通过光合作用的光反应将光能转化为化学能(NADPH和ATP),通过暗反应将大气中的二氧化碳同化,生成有机碳水化合物。光合产物(包括能量与有机碳)从叶绿体向胞质的运输是细胞内物质能量代谢的关键环节,使叶绿体和其他细胞区室间建立起关联关系,并对光合效率以及物质能量分配具有调控作用。本文从叶绿体光合产物的分子运输机制的角度,介绍光合电子传递速率、中心碳代谢以及胞内氧化还原态调控机制的研究进展,同时深入探讨了藻类和陆生植物通过调控光合产物运输适应多变自然环境的机制。然而,在光合细胞中,叶绿体被膜转运体的转运特性以及不同转运体是如何相互协作调控光合效率以及胞内代谢平衡仍有待深入研究。这些研究为定向编程叶绿体和胞质代谢流、提升光合效率提供了基础和元件。
黄伟超毕永红
关键词:光合效率
泰国人口贩运犯罪现状与治理
2024年
泰国长期以来不仅是人口贩运犯罪的源头国,而且是中转国和目的国。官方数据显示,泰国人口贩运案件被害人数和立案数从2017年至2020年逐步减少,但是性贩运案件立案数保持高位,渔业部门中劳动贩运案件情况严峻。为此,泰国从立法、执法和司法等方面采取了一系列应对措施,这些措施虽然由于其特殊的政治体制、官员的传统性别角色观念、社会秩序混乱和消极被动的治理态度等原因,导致实际效果欠佳,但其治理思路以及一些具体措施仍然有值得借鉴之处。
夏菲严榕
关键词:犯罪治理
网络贩毒案件的侦查难点与对策研究
2024年
随着信息化时代的到来,传统贩毒犯罪逐步转变为网络贩毒犯罪,严重危害着我国公共安全和社会稳定。研究其现状,可以发现网络的隐蔽性加之毒品交易追求的高利润、低风险等特点导致贩毒人员将毒品贩卖的主战场从现实空间蔓延至虚拟空间,使得网络贩毒成为了传统贩毒模式的升级版本,这给侦查造成了极大的困扰,侦查机关面临着缉毒线索发现难、犯罪嫌疑人缉捕难、证据收集和证明难以及侦查协作开展难等诸多难题。对此,侦查机关要从建立信息共享机制、加强网络管理、注意侦查取证的合法性以及以寄递公司为突破口构建侦查协作格局等方面入手,达到能够预先控制、案后速控、动态追踪、深挖犯罪的侦查效果。
杨诺嘉
关键词:侦查难点侦查对策
Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies
2024年
Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of life.They are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many patients.Such long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).
Felix KohleMichael Schroeter
关键词:DISEASESAUTOIMMUNE

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陈剑峰
作品数:21被引量:61H指数:4
供职机构:中国科学院
研究主题:7-氨基头孢烷酸 酰化酶 整合素 分泌表达 高效分泌表达
全超
作品数:2被引量:0H指数:0
供职机构:南京大学模式动物研究所
研究主题:INTERACTION GLUT4 TRAFFICKING RALA INSULIN-STIMULATED
陈亮
作品数:2被引量:0H指数:0
供职机构:南京大学模式动物研究所
研究主题:INTERACTION GLUT4 TRAFFICKING RALA INSULIN-STIMULATED
陈帅
作品数:20被引量:0H指数:0
供职机构:南京大学
研究主题:闪存 心肌细胞 多码率 LDPC码 SKELETAL_MUSCLE
周嘉伟
作品数:49被引量:83H指数:5
供职机构:中国科学院上海生命科学研究院神经科学研究所
研究主题:帕金森病 蛋白质 发育 GDNF 星形胶质细胞