DOV216303 was synthesized via six procedures starting from 3,4-dichlorophenylacetic acid in an overall yield of 14%.The structure of the target compound was confirmed by 1H-NMR and MS.This improved method could avoid the usage of the expensive reagents,reduce the cost and increase the total yield.
2-Chiorethyl acrylate was synthesized by transesterification of methyl acrylate and 2-chloroethanol.The effects of species and amount of catalyst and inhibitor,material ratio and reaction temperature on reaction yield were investigated.The optimum reaction conditions were determined that the molar ration of p-toluenesulfonic acid,hydroquinone,methyl acrylate to 2-chioroethanol was 0.06:0.05:3:1 and reaction temperature was 100°C,Under these conditions,the conversion was 95%,yield 90%.
